Randomized controlled trials of the point application therapy for stable angina pectoris：a systematic analysis

Abstract:

Objective：To evaluate the effectiveness and safety of point application therapy in treating table angina pectoris（SAP）. Methods：An extensive search of 4 English medical databases（PubMed，CochraneLibrary，Clinicaltrials，MEDLINE），and 4 Chinese medical databases（WanFang，CBM，CNKI，VIP） was conducted. Randomized controlled trials（RCTs） in accordance with inclusion and exclusion criteria were included. And quality of enrolled studies was assessed. A Meta-analysis was performed by Review Manager 5.2 software. Results：After researching，a total of 9 RCTs were included. Only one of the included RCTs had a clear random method. The allocation concealment and blinding of all included studies were not sure. There were statistical differences in relieving angina symptoms between point application therapy group and drug therapy group（RR=1.13，95％CI=1.07-1.20，P=0.000）. There were statis－tical differences in ECG effect between point application group and western medicine group（RR=1.12，95％CI=1.04-1.20，P=0.002）. There were statistical differences in traditional Chinese medicine（TCM） syndrome between two groups（RR=1.14，95％CI=1.05-1.25，P=0.004）. In addition，3 trials reported adverse effects such as skin rash，gastrointestinal adverse reactions. Conclusion：The point application therapy appears to have beneficial effects on relieving angina symptoms and TCM syndromes in participants with SAP. However，the findings should be interpreted with caution due to the poor methodological quality and small sample of the included trials.