Association between SLCO1B1 521 T>C polymorphism and Statins effectiveness among Chinese population：a systematic analysis

Abstract:

Objective：To evaluate the association between SLCO1B1 gene 521 T>C polymorphism and Statins effectiveness among Chinese population. Methods：Databases including PubMed，Web of Science，Embase，Cochrance Library，CNKI，WanFang Data and VIP were searched to retrieve the relevant references from the start to June 2014. A quality assessment was performed using the Methodological Index for Non-Randomized Studies（MINORS） criteria. Meta-analysis，sensitivity analysis（Revman 5.2），publication bias measuring were all done（Stata 12.0）. Results：A total of 5 studies were included for final meta-analysis，involving 812 partici－pants. Overall，there was no statistically significant association for the four genetic models of hypolipidemic effect. The dominant ge－netic model TC + CC vs. TT（MD=-0.38，95%CI=-1.91 to 1.14，P=0.62），recessive model CC vs. TT + TC（MD=0.09，95%CI=-1.77 to 1.96，P=0.92），the additive genetic model CC vs. TT（MD=-0.03，95%CI=-2.34 to 2.28，P=0.98） and TC vs. TT（MD=0.00，95%CI= -1.95 to 1.95，P=1.00）. Conclusion：There is no association between SLCO1B1 521 T>C polymorphism and Statins effectiveness among Chinese population.