Expression of HIF-1α and miR-210 in cervical squamous cell carcinoma and their relationship

Abstract:

Objective：To explore the correlation between hypoxia induced factor-1α（HIF-1α） and MicroRNA210（miR-210） in cer－vical cancer． Methods：The expression of HIF-1α protein was detected by immunohistochemistry. Poly（A）-RT-qPCR was used to de－tect the expression of miR-210 in cervical cancer and normal cervical tissues. The correlation between the expression of miR-210 and HIF-1α was analyzed in cervical cancer. Results：The expression of HIF-1α in cervical cancer was 73.1% （38/52），but HIF-1α was not detected in normal cervical tissues；the expression of miR-210 was significantly increased in cervical cancer tissues than in normal cervical tissues（P=0.000）. The expression of miR-210 in normal cervical tissues and cervical cancer was 1.16±0.76 and 5.04±1.28，respectively. The expression of HIF-1α and miR-210 were positively correlated in 52 cases of cervical cancer（r=0.43，P=0.001）. The expressions of HIF-1α and miR-210 were not correlated in normal cervical tissues. The expressions of HIF-1α and miR-210 were positively correlated in 72 cases（r=0.67，P=0.000）. Conclusion：The expression of HIF-1α and miR-210 are highly expressed in SCC tissues. HIF-1α and miR-210 are positively correlated in cervical cancer. It is predicted that HIF-1α and miR-210 are re－lated with the occurrence and development of cervical cancers，which is conductive to revealing the pathogenesis of cervical cancer.