Changes of the oncoproteins of breast cancer treated with neoadjuvant chemotherapy

Abstract:

Objective：To evaluate the changes of the oncoproteins of breast cancer treated with neoadjuvant chemotherapy（NAC）（Docetaxel+Epirubicin/Pirarubicin+Cyclophosphamide）. Methods：From 2012 to 2013，112 patients treated with NAC were included in this retrospective study. Data were analyzed using chi-square and t-test. Results：The highest changing rate from positive to negative was Ki-67（37.5%），while the lowest rate was estrogen receptor（ER） and P53（both 16.1%） respectively. The highest changing rate from negative to positive was P53（16.1%），while the lowest rate was Ki-67（2.7%）. Significant changes were observed in ER（P=0.043），Ki-67（P<0.001）、HER2（P=0.035），breast cancer subtype（P<0.001） and proliferative fraction of Ki-67（P<0.001）. Conclusion：NAC could make oncoproteins change. General information，such as age，obesity，lymph node，etc has a relationship with the changes of on－coproteins.