Preliminary exploration of androgen levels of healthy reproductive-age women in Chongqing

Abstract:

Objective：To explore the individual reference intervals of total testosterone（TT），free testosterone（FT），free androgen in－dex（FAI） and dehydroepiandrosterone sulfate（DHEAS） of healthy reproductive-age women in Chongqing. Methods：Totally 121 healthy reproductive-age women were enrolled，and serum TT，DHEAS，SHBG were measured，then FT and FAI were calculated.The （x±1.96 s） was calculated as the reference intervals of TT，cFT，DHEAS，and the 2.5th and 97.5th percentiles were calculated as the reference intervals of FAI. Results：（1）TT，cFT and DHEAS were in normal distribution，with levels of （0.46±0.16） ng/ml，（5.92±2.80） pg/ml，（222.81±86.82） μg/dl，respectively. However，FAI was in skewed distribution with the median and interquartile spacing of 2.60%（1.87-3.56）%. （2）The 95% individual reference intervals of TT，cFT，FAI and DHEAS were （0.15-0.77） ng/ml，（0.43-11.40） pg/ml，（0.90-9.34）%，（52.64-392.98） μg/dl，respectively. Conclusion：The individual reference intervals of TT，cFT，FAI and DHEAS of healthy reproductive-age women in Chongqing are preliminarily established.