Efficacy and safety of CZF versus microwave apparatus in the treatment of chronic cervicitis：a Meta-analysis

Abstract:

Objective：To evaluate the efficacy and safety CZF in the treatment of chronic cervicitis. Methods：Databases of Medline，Embase，Pubmed，Chinese biomedical literature database（CBM），VIP，CNKI and Wangfang digital journals（WF） were searched for randomized controlled trials（RCTs） or comparative study of CZF in the treatment of chronic cervicitis. Quality of enrolled literature was assessed and software of RevMan 5.2 was employed to conduct Meta-analysis. Results：A total of 9 RCTs were included，including 4 336 patients（treatment group：2 890 patients，control group：1 446 patients）. Meta-analysis results suggested that the treatment group had a higher total effective rate（RR=1.08，95%CI=1.04 to 1.13，P=0.000） than control group. Against a specific classification of chronic cervicitis，the treatment group and control group had no significant difference in the treatment of mild chronic cervicitis（RR=1.00，95%CI=0.99 to 1.02，P=0.72），but the treatment group had a higher effective rate in the treatment of moderate chronic cervicitis（RR=1.07，95%CI=1.01 to 1.14，P=0.02）and severe chronic cervicitis（RR=1.24，95%CI=1.09 to 1.42，P=0.001） than control group. Moreover，cases having less vaginal drainage（RR=0.25，95%CI=0.11 to 0.56，P=0.000），vaginal bleeding（RR=0.14，95%CI=0.08 to 0.25，P=0.000），scabby（RR=0.01，95%CI=0.00 to 0.07，P=0.000） and scarring（RR=0.01，95%CI=0.00 to 0.02，P=0.000） were fewer in treatment group than in control group. Conclusion：CZF for chronic cervicitis is more effective than microwave therapy instrument and it can reduce adverse reac－tions and sequelae.