Association between TNFAIP3 gene polymorphisms and susceptibility of allergic rhinitis in a Chinese Han population

Abstract:

Objective：To evaluate the potential association of tumor necrosis factor alpha-inducible protein 3（TNFAIP3） gene poly－morphisms and the susceptibility of allergic rhinitis（AR） in the Chinese population. Methods：Four single nucleotide polymorphisms （SNPs） of TNFAIP3 were genotyped in 430 AR patients and 480 health controls using a polymerase chain reaction-restriction frag－ment length polymorphism assay（PCR-RFLP）. Results：Prevalences of the rs9494885 TT genotype（PC=7.51×10-12） and T allele（PC=3.79×10-12）were found significantly increased in patients with AR. An conspicuous decreasing prevalence of the CT genotype（PC=3.30×10-11） and C allele（PC=3.79×10-12）was shown in patients with AR. In addition，the CACA haplotypes（PC=3.29×10-10） were decreased in patients，whereas TCCA haplotypes（PC=2.18×10-3） were increased. Conclusion：One novel SNPs of TNFAIP3 gene，rs9494885 is associated with susceptibility of AR.