Lipid accumulation product as an effective index for accessing insulin resistance in patients with adult growth hormone deficiency

Abstract:

Objective：To investigate the correlation of lipid accumulation product（LAP） with anthropometrics，glucolipid metabolic markers and insulin resistance（IR） in patients with adult growth hormone deficiency（AGHD）. Methods：Totally 42 patients with AGHD and 42 control subjects matched with the age and gender were enrolled. The general anthropometries and blood biochemical indexes were measured. Body mass index（BMI），waist-hip ratio（WHR），LAP and HOMA-IR were calculated. Results：Compared with those in control group，the waist circumference（WC），WHR，fasting insulin（FINS），homeostasis model assessment of insulin resistance（HOMA-IR），triglyceride（TG） and LAP were increased in AGHD group，while high density lipoprotein-cholesterol（HDL-C） level was lower in AGHD group（P＜0.05）. Weight，BMI，WC，WHR，SBP，DBP，FINS，HOMA-IR and TG increased as LAP increased（P＜0.05）. Pearson analysis revealed that LAP was positively related with age，BMI，WC，HC，WHR，systemic blood pressure（SBP），dias－tolic blood pressure（DBP），FINS，HOMA-IR，TG and low density lipoprotein cholesterol（LDL-C）（P＜0.05）. After age was adjusted，the positive correlations were still existed（except DBP）. In ad－dition，HOMA-IR was positively correlated with BMI，WC and TG（P＜0.05）. LAP was higher in AGHD patients with IR. ROC analysis showed that LAP was a significant discriminator for IR in AGHD patients，and the optimal cutoff point of LAP to pre－dict IR was 31.32（90.9% sensitivity，61.30% specificity）. Fur－ther more，multivariable linear regression models revealed that BMI，SBP，HOMA-IR were independently related with the LAP（β=0.414，0.249，0.329，resp，P<0.05）. Conclusion：The LAP is sig－nificantly higher in AGHD patients than control subjects. LAP is associated with IR and had a strong and reliable diagnostic accuracy for IR in AGHD patients.