Therapeutic effect of valsartan and amlodipine SPC on primary hypertension with stable angina pectoris

Abstract:

Objective：To evaluate the efficacy and safety of valsartan and amlodipine SPC for treating hypertensive patients with stable angina pectoris. Methods：Totally 122 patients were randomly divided into group A（60 cases） and group B（62 cases）. Group A was given valsartan and amlodipine tablets treatment while Group B was given valsartan and hydrochlorothiazide tablets treatment. Both treatments lasted for 6 weeks. The blood pressures，exercise treadmill test results，resting ECG，stable angina pectoris of two groups，before and after the treatment，were monitored and the adverse drug reactions and compliance were observed. Results：The treatment of group A showed better antihypertensive effect than that of group B（group A vs. group B，P=0.000，P=0.035），and the difference was statistically significant. There were statistical significant differences in exercise treadmill test results（P=0.001，P=0.034，P=0.000，P=0.000，P=0.029，P=0.000），resting ECG（P=0.000），coronary artery events（P=0.000）between group A and group B. There was no significant difference in adverse reactions（P=0.585） and compliance evaluation（P=0.768） of both groups. Conclusion：The treatment based on valsartan and amlodipine tablets is a better treatment in smoothly lowering blood pressure and effectively reducing the stable angina pectoris，sudden coronary events，and there is no significant difference in drug safety and compliance compared with that of the other first-line antihypertensive drugs.