Clinical value of interferon-γ releasing assay in differentiating intestinal tuberculosis and Crohn’s disease：a systematic review

Abstract:

Objective：To evaluate the value of two interferon-γ releasing assays（IGRA） in differential diagnosis of intestinal tubercu－losis（ITB） and Crohn’s disease（CD）. Methods：Datebases of Embase，PubMed，EBM Reviews，CNKI，WanFang were searched for evaluating the value of IGRA in differential diagnosis of ITB and CD. The Meta-Disc was used to calculate the pooled sensitivity，specificity and 95% confidence interval（95%CI）. Summary receiver operating characteristic curve（SROC），area under curve（AUC） and Q* were used to evaluate the efficiency of the two methods. Results：Totally 12 articles were included，including 854 patients（ITB 367，CD 487）. The pooled sensitivity and specificity for T-SPOT TB were 0.89（95%CI=0.84 to 0.93） and 0.85（95%CI＝0.81 to 0.89）. The pooled sensitivity and specificity for Quantiferon-TB were 0.72（95%CI=0.64 to 0.79） and 0.92（95%CI=0.86 to 0.96）. The AUC of SROC for the two methods were 0.9450 and 0.9110，and the Q* were 0.883 9 and 0.843 2. There was no statistically difference between the two methods（P=0.164）. Conclusion：T-SPOT.TB and Quantiferon-TB are both effective ways for the differ－ential diagnosis of ITB and CD. But there was no statistically difference between the two methods.