Association between ABCA1 gene R1587K polymorphism and coronary heart disease susceptibility：a systematic review

Abstract:

Objective：To investigate the association between ATP binding casette transporter A1（ABCA1） gene R1587K polymorphism and coronary heart disease susceptibility. Methods：Literature was retrieved in electronic databases covering PubMed，Web of Science，CNKI，WanFang and VIP up to Jun，2014 to collect the case-control studies on ABCA1 gene R1587K polymorphism and coronary heart disease susceptibility. The odds ratios（ORs） and 95% conidence intervals（CIs） were taken as the effect indexes，either the fixed or random effect model was applied to conduct Meta-analysis by Stata 11.0 software in heterozygote，homozygote，dominant，and recessive genetic models，respectively. Results：A total of 5 case-control studies were identified，involving 2 032 cases and 11 492 controls. The current Meta-analysis showed that the AB－CA1 gene R1587K polymorphism was significantly associated with coronary heart disease under homozygote and dominant genetic model（homozygote：OR=1.140，95%CI=1.028~1.266，POR=0.014；dominant：OR=1.124，95%CI=1.017~1.243，POR=0.022）. Subgroup analysis results by ethnicity were significantly associated with Caucasian. Conclusion：The current Meta-analysis suggests that ABCA1 gene R1587K polymorphism might be associated with coronary heart disease susceptibility in Asian. Further studies are needed to val－idate the above conclusion.