Systematic review of efficacy of pseudomonas aeruginosa-mannose sensitive hemagglutinin for tumor

Abstract:

Objective：To systematically evaluate the efficacy of pseudomonas aeruginosa-mannose sensitive（PA-MSHA） for tumor. Methods：Randomized controlled trials（RCTs） about the efficacy of PA-MSHA on tumor were retrieved in Pubmed，Sciverse，Cochrone Library，CNKI，CBM，VIP and WanFang databases up to November，2014. According to the inclusion and exclusion criteria，two reviewers independently screened the trials，extracted the data，assessed the quality，conducted the Meta-analysis with Revman 5.3 finally. Results：A total of 10 RCTs were eligible for the study including 611 cases. The pooled results showed that complete re－mission（CR）（RR=1.95，95%CI=1.37 to 2.79，P=0.000 2） and overall response rate（RR）（RR=1.95，95%CI=1.37 to 2.79，P=0.000 2）were increased and progression rate of disease（PD） RR=0.42，95%CI=0.24 to 0.71，P=0.001）was decreased in experiment groups，however，partial response rate（PR） and stability rate of disease（SD） were not different in both two groups. Meanwhile，the count of CD3（SMD=0.93，95%CI=0.16 to 1.70），P=0.02），NK cell（SMD=1.40，95%CI=0.26 to 2.53，P=0.02），IFN-γ（MD=16.92，95%CI=12.88 to 20.96，P=0.000）was higher in experiment group than in control group. There was no statically difference in the number of CD4，CD8 and between two groups. Karnofsky scores were also higher in experiment group than in control group. The pooled results of subgroup analysis indicated that CR（P=0.006），PD（P=0.04） and NK cell（P=0.000） were increased in experiment group in lung cancer patients. RR（P=0.01） and Karnofsky scores（P=0.000） were also increased in experiment group in breast cancer patients. The results also showed that neo-adjuvant chemother－apy with PA-MSHA could improve Karnofsky scores（P=0.000 2）. Chemotherapy with PA-MSHA could improve CR（P=0.000 2），PD（P=0.003） and Karnofsky scores（P=0.000），oppositely，there was no difference in PR（P=0.73） and SD（P=0.39） between the two groups. Conclusion：PA-MSHA can effectively increase treat the tumor and enhance host anti-tumor function. PA-MSHA should be widely used in tumor administration in clinical application.