Muscarinic antagonists combined with non drug therapy for overactive bladder in adult female：a systematic review

Abstract:

Objective：To assess the therapeutic effects of muscarinic antagonists combined with non drug therapy or overactive bladder（OAB） in adult female. Methods：Published randomized controlled trials（RCTs）on muscarinic antagonists combined with non drug therapy and muscarinic antagonists therapy in the treatment of overactive bladder（OAB） in adult female were searched from PubMed，Embase，Web of Science，CNKI，CBWMDisc，Wanfang，VIP and other databases before January 2015 according to pre-specified stan－dard. Studies were qualified according to Jadad scale，and were analyzed using Revman5.3. Results：Totally 7 articles（610 patients），including 4 articles about muscarinic antagonists combined with electrical stimulation，2 articles about muscarinic antagonists com－bined with behavior training，1 article about muscarinic antagonists combined with both above. The meta-analysis showed that：① There was no difference in the average daily frequency of urination（WMD=-0.60，95%CI＝-1.23 to 0.03，P=0.06） and frequency of urinary incontinence（SMD=-4.45，95%CI＝-12.77 to 3.86，P=0.29）. Frequency of urgency（WMD=-1.09，95%CI＝-2.15 to -0.03，P=0.04） significantly decreased and total clinical efficiency（RR=1.24，95%CI＝1.06 to 1.44，P=0.007） improved obviously in the mus－carinic antagonists combined with electrical stimulation group compared with those of control group. ②Efficacy of muscarinic antago－nists combined with behavior training group was better than control group in reducing the average daily frequency of urination（WMD=-0.67，95%CI=-1.14 to -0.20，P=0.005）. Conclusion：Compared with single muscarinic antagonists therapy，the muscarinic antagonists combined with non drug therapy can better improve the partial urinary symptoms in adult female patients with OAB，and improve the total clinical efficiency.