Association of the single nucleotide polymorphisms of MEF2A with coronary artery disease in Chinese Han population

Abstract:

Objective：To investigate the association of single nucleotide polymorphism（SNP rs325400 and rs34851361） of MEF2A gene on chromosome 15q26 with coronary artery disease（CAD）. Methods：A case-control association study of 90 unrelated CAD patients and 130 normal controls from a Chinese Han population was performed. Genotype and allele were determined by polymerase chain reaction（PCR） and nucleotide sequencing for SNP rs325400 and rs34851361 in MEF2A gene. Results：The frequencies of the geno－type and alleles of rs325400 in MEF2A had statistical significance between two groups（P＜0.05），but there was only the AA in both groups of rs34851361. Conclusion：The present findings suggest that the genetic polymorphism in rs325400 may be associated with the development of the CAD in Chinese Han population and the attack rate of the CAD in the crowd with allele A may be higher.