Release profile and intestinal absorption of evodiamine complex oil-in-water nanoemulation

Abstract:

Objective：To study its in vitro drug release of evodiamine nanocomplex oil-in-water nanoemulation（OECNE）and to inves－tigate its intestinal absorption. Methods：The dialysis was used to evaluate release profile，and the release behavior was studied by model and similarity factor f2. Single-pass intestinal perfusion was conducted to evaluate intestinal absorption. Results：The cumula－tive releases of OECNE were both about 3-fold that of EDA in 0.1 pH 1.2 hydrochloric acid solution and in pH 6.8 phosphate buffer solution，and OECNE was in accordance with Weibull model in two different solutions，and f2 also revealed OECNE have benefit in drug release. The intestinal absorption rate constant of OECNE was 2.32-fold，2.74-fold，3.36-fold，4.13-fold and 2.74-fold than that of free EDA in stomach，duodenum，jejunum，ileum and colon. The effective permeability of OECNE was 4.66-fold，3.70-fold，4.87-fold and 3.60-fold than that of EDA. Conclusion：OECNE was successfully used to enhance the absorption of EDA.