Clinical significance of the expression of intercellular adhesion molecule-1 and lymphangiogenesis in cervical cancers

Abstract:

Objective：To investigate the expression of intercellular cell adhesion molecule-1（ICAM-1） and the lymphatic vessel density（LVD） of D2-40 markers in cervical cancer tissues，and their relationship with clinicopathological factors. Methods：From Mar 2015 to Apr 2016，38 patients with cervical cancers undergoing surgical excision in our hospital were enrolled as experimental group，while 30 samples of the normal cervical tissue and 30 samples of the cervical intraepithelial neoplasia（CIN） tissue from patients undergoing uterus operation in the same period，with age matched，were selected as the control group. Results：There was no significant difference in the baseline information among the three groups. The expression of LVD and ICAM-1 in normal cervical and CIN tissues were sig－nificantly lower than that in cervical cancer tissues，and the difference was statistically significant（P<0.01）. The differences in the ex－pression of ICAM-1 and LVD in cervical cancers were correlated with the invasion depth，lymph node metastasis and FIGO staging. The LVD value in 26 cases of cervical cancers with ICAM-1 positive expression was （15.13±3.22），but in 12 cases of cervical cancers with negative expression，it was （9.85±2.48），and the difference was statistically significant（t=5.021，P=0.004）. Conclusion：LVD and the expression of ICAM-1 in cervical cancers were significantly higher than that in normal cervical tissues，and they were closely related with the lymph node metastasis of cervical cancers.