Regulation of TGF-β and BMPs signal pathways on abnormal proliferation in pulmonary artery smooth muscle cells

Abstract:

The transforming growth factor-β（TGF-β） superfamily is composed of many cytokines，mainly including of TGF-βs and bone morphogenetic proteins（BMPs）. Recently，antagonism effect between TGF-βs and BMPs on proliferation in pulmonary artery smooth muscle cells is showed. Furthermore，individual genes variation might cause to different，even opposite effects of TGF-βs or BMPs on the proliferation. This article reviewed the regulation of TGF-β and BMPs signal pathways on abnormal proliferation in pul－monary artery smooth muscle cells.