Primary aldosteronism associated with rhabdomyolysis： a report of 2 cases and review of the literature

Abstract:

Objective：To investigate the clinical features of primary aldosteronism associate with rhabdomyolysis and to guide the diag－nosis and treatment of the disease. Methods：The presentation and symptoms of the two patients in our hospital were described and the relevant literature was reviewed. A thorough literature search disclosed 19 further cases of rhabdomyolysis due to undiagnosed pri－mary aldosteronism. Results：All patients had a history of hypertension，including fatigue，myalgia，hypokalemia and high muscle en－zymes，and there were a small number of patients who had abnormal myoglobinuria，acute renal failure and abnormal liver enzyme. Rhabdomyolysis was cured by a large amount of fluid and urine alkalization. All patients were restored to normal blood pressure and normal serum potassium levels after drug or adrenal surgical interventions. Conclusion：For the high risk population of primary aldos－teronism，early screening should be conducted to prevent disease progression and serious complications such as rhabdomyolysis，and for patients with dignosed primary aldosteronism whose serum potassium is lower than 2.0 mmol/L，rhabdomyolysis should be alerted. Primary aldosteronism patients with rhabdomyolysis should actively receive symptomatic treatment and cure the primary disease.