Research progress of myocardial cation channels and myocardial ischemia reperfusion injury

Abstract:

Myocardial ischemia-reperfusion injury（MIRI） is a common complication of ischemic myocardium after restoring blood flow. A large number of studies have shown that some of the cationic channels distributed in the myocardial cell membrane and related organelles are involved in the related pathophysiological processes of MIRI. Early studies have found that Na+，K+ and Ca2+ channels are involved in the MIRI process. Recent studies find that transient receptor potential（TRP） is also involved in MIRI and may be the new interfering target of medicine treatment. This paper aims to review the roles of the myocardial cation channels such as Na+，K+，Ca2+ and TRP in MIRI.