Research progress in dental pulp regeneration strategy based on endogenous stem cell homing

Abstract:

By now，the standard treatment method for teeth with irreversible dental pulp inflammation and necrosis is root canal therapy. However，it cannot restore the physiological function of dental pulp dentin complex and form the reparative dentin to resist external invasion. Compared with traditional root canal surgery，inducing dental pulp regeneration in the root canal has a better prognosis and is the future research direction. It has been showed that dental pulp structure and tubular dentin can be formed by implanting stem cells，suitable scaffold materials，and signal factors into the root canal based on tissue engineering principle. Compared with the exogenous stem cell transplantation with technical sensitivity and potential safety problems，the dental pulp regeneration strategy based on endogenous cell homing can meet the clinical requirements. Current status and research progress in dental pulp regeneration strategy based on endogenous stem cell homing are summarized as follows.