Risk factors for vitamin D deficiency and insufficiency in patients with Graves disease in Nanning，Guangxi Province，China

Abstract:

Objective：To investigate the clinical characteristics of different vitamin D status in patients with Graves disease（GD） and the risk factors for vitamin D deficiency and insufficiency in GD patients. Methods：The medical data of 328 patients with GD were collected. These patients were divided into two groups according to their vitamin D levels：vitamin D deficiency and insufficiency group [25（OH）D3 <75mmol/L] and vitamin D sufficiency group[25（OH）D3≥75mmol/L]. Age，sex，the levels of thyroid stimulating hor－mone，free triiodothyronine，free thyroxine，thyrotropin receptor antibody（TRAb），thyroid peroxide antibody（TPOAb），and thyroglobu－lin antibody（TGAb） were compared to investigate the clinical characteristics of these two groups. Univariate and multivariate logistic regression analyses were used to identify the risk factors for vitamin D deficiency and insufficiency in patients with GD. Results：The prevalence of vitamin D deficiency and insufficiency in GD patients was 64.02%. The age of the vitamin D deficiency and insuffi－ciency group was significantly younger than that of the vitamin D sufficiency group （34.89±12.25 vs. 39.11±11.97，P<0.05）. There were significant differences in sex and seasonal compositions between the two groups（both P<0.05）. The multivariate logistic regression analysis showed that the risk factors for vitamin D deficiency and insufficiency in GD patients were sex and season；no association with thyroid antibody，thyroid function，or liver function was found（P >0.05）. The risk of vitamin D deficiency and insufficiency in fe－male GD patients was 3.052 times higher than that in male GD patients（odds ratio[OR]=3.052，95% confidence interval（CI）：1.641 to 5.676，P<0.05）. Moreover，the risk of vitamin D deficiency and insufficiency in winter was 2.173 times higher than that in summer（OR=2.173，95% CI=1.303 to 3.623，P<0.05）. Conclusion：The risk of vitamin D deficiency and insufficiency is higher in female GD patients than in male GD patients and in winter than in summer，which prevention measures should be taken for. In the mean－time，the above risk factors should be adjusted when studying the vitamin D level in GD patients.