Progress in the Abnormal expression and function of LncRNA in thyroid cancer

Abstract:

Thyroid cancer is the most common endocrine malignancy，and its incidence has increased rapidly in recent decades and has become a major health problem. In recent years，our understanding of the molecular mechanisms of thyroid cancer has made sig－nificant progress，with significant advances in diagnosis，prognosis and treatment，but there are still cases where the risk of developing more aggressive and fatal thyroid cancer. The discovery of long non-coding RNA（lncRNA） has dramatically changed our understand－ing of cell biology，especially the pathophysiology of cancer. Several studies have demonstrated that they have key regulatory roles in gene expression，cell biological behavior and carcinogenesis. Deregulated expression levels of lncRNA have been observed in various types of cancer including thyroid cancer，however，their role and molecular mechanism in thyroid cancer remains unclear. In this re－view，we summarize recent literature to highlight the current status of such lncRNAs in thyroid cancer.