Mechanism of action of metformin in bone mineral metabolism

Abstract:

Metformin，as a classic oral hypoglycemic agent for the treatment of type 2 diabetes，has been shown to have a positive ef－fect on bone mineral metabolism in recent years，but its mechanism of action is very complicated，including inducing osteoblast differ－entiation，reducing the number of osteoclasts，and reversing the apoptosis of osteocytes and osteoblasts directly or indirectly induced by hyperglycemia. This article reviews the research advances in this field.