Bone mineral density of Tibetan patients with type 2 diabetes and related risk factors

Abstract:

Objective：To investigate the bone mineral density of Tibetan patients with type 2 diabetes and related risk factors，and to provide a theoretical basis for the prevention and treatment of osteoporosis in type 2 diabetes among the Tibetan population in Tibet. Methods：The patients with type 2 diabetes who were hospitalized in Department of Endocrinology，The People’s Hospital of Tibet Autonomous Region，from January 2016 to March 2018 were enrolled，and their general information and biochemical parameters were collected. According to the T value of dual-energy X-ray absorptiometry，they were divided into normal group（T value ≥-1.0），low bone mass group（T value ranging from -2.5 to -1.0），and osteoporosis group（T value ≤-2.5）. The three groups were compared in terms of general information and biochemical parameters，and a multiple linear regression analysis was performed for the data and pa－rameters with differences to identify risk factors. Results：A total of 456 patients（286 male and 170 female patients） were enrolled in this study，with a mean age of 55.7±11.3 years. There were significant differences between the three groups（177 patients in the nor－mal group，202 in the low bone mass group，and 77 in the osteoporosis group） in age，course of disease，body mass index（BMI），uric acid，and high-density lipoprotein cholesterol（all P<0.05），while there were no significant differences in fasting blood glucose，HbA1c，blood calcium，blood magnesium，serum phosphorus，triglyceride，cholesterol，low-density lipoprotein cho-lesterol，alkaline phosphatase，25-hydroxyvitamin D，and para-thyroid hormone（all P >0.05）. Uric acid was a risk factor for reduced bone mass in the lumbar ver－tebra（β=0.215，P <0.05），and age，BMI，and uric acid were risk factors for reduced bone mass in the femoral neck（β=-0.329，0.177，and 0.173，all P <0.05）. Conclusion：Old age，low BMI，and low uric acid are risk factors for reduced bone mass in Ti－betan patients with type 2 diabetes and should be taken seri－ously in clinical practice.