Expression and clinical significance of T-cadherin in acute promyelocytic leukemia

Abstract:

Objective：To investigate the expression and clinical significance of T-cadherin in patients with acute promyelocytic leukemia（APL）. Methods：A total of 60 patients with APL and 60 healthy subjects who underwent physical examination were en－rolled，and immunohistochemistry was used to measure the expression of T-cadherin in bone marrow biopsy samples. The association of the expression of T-cadherin with clinicopathological features, clinical outcomes, and survival/prognosis was analyzed. Results：The low and high expression rates of T-cadherin were 71.7% and 28.3% in APL patients and 25.0% and 75.0% in healthy subjects，and there was a significant difference between the two groups（?字2=26.162，P=0.000）. In APL patients，the expression of T-cadherin in bone marrow biopsy samples was associated with risk classification，percentage of promyelocytes，and recurrence（all P<0.05） and was not associated with age，sex，white blood cell count，hemoglobin，and platelet count（all P>0.05）. The multivariate Cox regression analysis showed that risk classification，percentage of promyelocytes，and low expression of T-cadherin were independent factors for recurrence in patients with APL（all P <0.05）. The low-T-cadherin expression group had a remission rate of 62.8% and an overall response rate of 69.8%，and the high-T-cadherin expression group had a remission rate of 88.2% and an overall response rate of 94.1%；there was no significant difference between the two groups（both P>0.05）. The log-rank test revealed that the five-year survival rate was 53.5% in APL patients with low expression of T-cadherin and 82.4% in those with high expression（?字2=4.294，P=0.035）. The Kaplan-Meier survival analysis showed that the patients with low expression of T-cadherin had a significantly lower 5-year survival rate than those with high expression（P=0.045）. Conclusion：There is low expression of T-cadherin in APL patients，which is associated with risk classification，percentage of promyelocytes，and recurrence. Therefore，T-cadherin may be an important predictor for survival/prognosis.