Effect of nutritional support therapy on the clinical efficacy of neuroblastoma in children

Abstract:

Objective：To evaluate the effect of nutritional support therapy on the clinical efficacy of nueroblastoma（NB）. Methods：A total of 106 children with NB admitted from October 2014 to December 2016 were enrolled and divided into the nutrition treatment group（group A，52 cases） and non-nutritional treatment group（group B，54 cases）. The nutritional status of the two groups at the ini－tial diagnosis was evaluated，and the nutritional indicators，the incidence of complications and the health economics index of the two groups after operation and chemotherapy were analyzed respectively. Results：①The middle upper arm circumferences of the children in group A at the initial diagnosis，after operation and after chemotherapy were （8.2±2.6），（9.5±2.2），and （9.8±2.0） cm respec－tively，while those in group B were （7.0±2.3），（6.5±1.4），（6.5±1.2） cm respectively. The deltoid skin fold thicknesses of the children in group A were （4.8±1.2），（6.2±1.6），（6.4±1.5） mm respectively，while those in group B were （3.9±3.4），（4.5±1.2），（4.6±1.1） mm respectively. The difference between the two groups was significant（P<0.05），and the differences among each two of the three time points in group A were also significant（P<0.05），while which in group B were not significant（P>0.05）. ②Postoper－ative wound dehiscence and infection complications in children were 1.9% in group A and 18.5% in group B，and the difference between the two groups was significant（P<0.05）. ③After 4 courses of chemotherapy，the incidences of myelosuppression，gastrointestinal symptoms and respiratory tract infection in group A were significantly lower than those in group B（P<0.05）. ④The average hospitalization duration，times，and cost，and the unplanned readmission rate in group A were also significantly lower than those in group B（P<0.05）. Conclusion：The standardized nutrition support treatment for NB children can effectively improve the nutritional status，reduce the incidence of complications caused by surgery and chemotherapy，and improve the tolerance of children to tumor treatment.