Relationship between internal carotid artery curvature and intracranial aneurysm in oxidative stress induced by H2O2

Abstract:

Objective：To observe the occurrence of internal carotid artery curvature in patients with intracranial aneurysm，and to in－vestigate whether there is correlation between internal carotid artery curvature and intracranial aneurysm. Methods：The general case data of 177 patients with aneurysms（patients with ruptured aneurysms and unruptured aneurysms） and 164 patients without a－neurysms（control patients） were retrospectively analyzed by case-control study. The internal carotid artery curvature was divided into no，tortuosity，kinking and coiling by computed tomogrphy angiography（CTA） images. Univariate analysis was performed on the degree of carotid artery tortuosity and general data between the aneurysm group and the control group，and then the multivariate logistic regression analysis was used to analyze the statistical significance factors of univariate analysis. Finally，the correlation between aneurysm-related features and internal carotid artery curvature was analyzed. Results：Kinking was 47 cases（26.6%） and 26 cases （15.9%） in the aneurysm group and in the control group. Univariate analysis showed that kinking was significantly correlated with the incidence of intracranial aneurysms（P=0.016）. Multivariate logistic regression analysis showed that kinking was an independent factor affecting the occurrence of intracranial aneurysms（P=0.002，OR=2.573，95%CI=1.426 to 4.641）. There was no correlation between internal carotid artery curvature and intracranial aneurysm rupture，size and number. Conclusion：Internal carotid artery curvature is one of the factors affecting the occurrence of intracranial aneurysm.