Correlation between serological markers for liver cirrhosis and Child-Pugh class

Abstract:

Objective：To investigate the correlation between serological markers for liver cirrhosis and Child-Pugh class and its clini－cal significance. Methods：A total of 235 patients with liver cirrhosis who were treated in Department of Infectious Diseases in The Second Affiliated Hospital of Chongqing Medical University from July 2016 to April 2017 were enrolled，among whom 55 had Child-Pugh class A cirrhosis，90 had Child-Pugh class B cirrhosis，and 90 had Child-Pugh class C cirrhosis，and 35 individuals who under－went physical examination during the same period of time were enrolled as controls. The indices including liver function parameters，liver fibrosis indices，and platelet count were measured and analyzed. Results：There were significant differences between the two groups in hyaluronic acid（HA），laminin（LN），type Ⅲ collagen（PC-Ⅲ），type Ⅳ collagen（Ⅳ-C），aspartate aminotransferase（AST），alanine aminotransferase（ALT），and aspartate aminotransferase-to-platelet ratio index（APRI）（P<0.05）. HA，PC-Ⅲ，Ⅳ-C，LN，and AST had an area under the ROC curve of 0.910，0.804，0.833，0.753，and 0.730，respectively. HA，PC-Ⅲ，and Ⅳ-C were positively correlated with Child-Pugh class（r>0.7，P<0.01），and APRI was positively correlated with Child-Pugh score（0.4