A study of the correlation of iodine nutrition with SOD，IP-10，and thyroid hormone in elderly patients with Hashimoto’s thyroiditis

Abstract:

Objective：To investigate the correlation of iodine nutritional status with superoxide dismutase（SOD） activity and levels of interferon-inducible protein 10（IP-10） and thyroid hormone in elderly patients with Hashimoto’s thyroiditis（HT）. Methods：A total of 92 elderly patients with HT who visited the Department of Endocrinology in Tangshan Workers’ Hospital and 40 clinically healthy elderly subjects who had physical examinations during the same period were tested for their serum SOD activity，levels of urine iodine and IP-10，and other indices related to thyroid function. SOD activity，the levels of IP-10 and thyroid hormones，and the incidence of HT were compared between the subjects with different nutritional status. The correlation between iodine，SOD，and IP-10 was analyzed. Results：Compared with the control group，the elderly patients with HT had higher mean levels of urinary iodine（216.63 μg/L） and IP-10（194.41 ng/L），but lower SOD activity（92.99 U/mL）. The group with adequate iodine had significantly increased levels of thyroid stimulating hormone，free triiodothyronine，free thyroxine，and IP-10，but significantly decreased SOD activity. A correlation analysis showed that urinary iodine was negatively correlated with SOD activity and positively correlated with serum IP-10 level，and serum SOD activity was negatively correlated with the IP-10 level（r=0.662）. Conclusion：Excessive iodine intake is associated with HT in the elderly. High iodine level can affect the thyroid function，oxidative stress，and chemotactic factor level of patients.