Abstract:Alzheimer’s disease (AD) is the most common type of senile dementia with a high prevalence rate, but there are still no effective prevention and treatment measures. AD is regarded as a central nervous system disease in traditional views, but recent studies have shown that systemic factors are closely associated with AD. Two major pathogenic substances of AD, β-amyloid and tau protein, are metabolized in both central and peripheral pathways, and the central and peripheral clearance pathways are involved in the development and progression of AD. This article discusses the pathogenesis of AD and related prevention and treatment strategies from a systemic view.
