Abstract:Both type 2 diabetes and cognitive impairment are chronic diseases that greatly threaten the quality of life of human beings, and they are also important health issues in the elderly population. The incidence rates of these two diseases keep increasing in most parts of the world. The pathogenesis of cognitive impairment caused by type 2 diabetes remains unclear, and possible factors and mechanisms include insulin resistance, hyperinsulinemia, association between insulin and β-amyloid metabolism, an increase in advanced glycation end products due to hyperglycemia, hypoglycemia, cerebrovascular diseases, dyslipidemia, and inflammatory factors. This article reviews the various factors and mechanisms of cognitive impairment caused by type 2 diabetes, in order to provide ideas for prevention and early intervention of cognitive impairment including Alzheimer’s disease.
