Research hotspots and development trends of α-synuclein

Abstract:

Objective：To investigate the research hotspots and development trends in the field of α-synuclein（αS）. Methods：CiteS－pace V was used for the visualization processing and analysis of 10 991 articles on αS in Web of Science Core Collection database from 1998 to 2017，to reveal the knowledge basis，research hotspots，and development trends of αS research. Results：The numbers of published articles and citations in the research on αS showed an exponential increase year by year. The US contributed significantly to the research in the field of αS. The high-frequent co-cited articles on αS mainly focused on the association between αS and Lewy body，αS gene mutations，αS aggregation，and Braak stages of Parkinson’s disease. The main research hotspots in the field of αS in－cluded αS-related diseases，in vitro studies，and the pathogenesis of Parkinson’s disease. The research frontiers and future research trends of αS were expected to focus on the biomarkers，autophagy and other pathogeneses，neuroprotective therapy，and mouse model of Parkinson’s disease. The scholars in China paid more attention to the pathogenesis and animal model of Parkinson’s disease. Conclusion：The research on αS has been developing rapidly around the world in recent years. This article analyzes the knowledge basis，research hotspots，and development trends of the research on αS and reveals the dynamic development of αS research over the past twenty years，which provides a reference for research in related disciplines.