Abstract:Objective: To investigate the clinical research advances in the effect of acupuncture and moxibustion in the treatment of autism spectrum disorders (ASD), depression, and senile dementia. Methods: With the method of a retrospective literature review, CNKI, VIP, Wanfang Data, and PubMed were searched for articles on the effect of acupuncture and moxibustion in the treatment of the above three brain diseases, and data analysis was performed based on etiology, pathogenesis, and principle of treatment. Results: Extensive research has been carried out on acupuncture and moxibustion for the treatment of the three brain diseases in recent years, and the large number of clinical studies had laid a foundation for the applicability and scientificity of this treatment. Conclusion: Acupuncture and moxibustion have a marked clinical effect in the treatment of brain diseases. Clinical practice guidelines of acupuncture and moxibustion should be published as soon as possible to standardize future clinical studies.