Abstract:In recent years, more and more attention has been paid to pain management in patients with amyotrophic lateral sclerosis. As a common non-motor symptom, pain affects the quality of life of patients severely. Pain is often neglected by clinicians in clinical practice, due to that it may be masked by the motor symptoms of amyotrophic lateral sclerosis. The pathogenesis of pain in amyotrophic lateral sclerosis is still unclear, which leads to little understanding of the nature, classification, and treatment of pain. This article describes the thinking and methods of pain management in amyotrophic lateral sclerosis by reviewing recent research results.