Clinical effect of compound articaine in endoscopic endonasal dacryocystorhinostomy

Abstract:

Objective：To investigate the clinical effect of compound articaine（Primacaine） for infiltration anesthesia in endoscopic en－donasal dacryocystorhinostomy（EN-DCR） combined with stent implantation. Methods：A prospective study was performed for 69 pa－tients who planned to undergo EN-DCR in the left nasal cavity，and these patients were randomly divided into control group with 30 patients（2% lidocaine for infiltration anesthesia） and experimental group with 39 patients（compound articaine for infiltration anes－thesia）. The two groups were compared in terms of effective proportion，visual analogue scale of pain（VASp） during surgery，preoper－ative/postoperative heart rate and blood pressure，and intraoperative bleeding. The chi-square test and the independent samples t-test were used for statistical analysis. Results：There were significant differences between the experimental group and the control group in VASp score（44.36±11.65 vs. 52.67±12.02，t=2.897，P=0.005） and intraoperative blood loss[（3.87±0.95） mL vs. （4.17±0.95） mL，t=2.698，P=0.007]. There was no significant difference in effective proportion between the experimental group and the control group（89.74% vs. 76.67%， ?字2=1.298，P=0.2５５）. There were also no significant differences between the two groups in blood pressure and heart rate before and after surgery（P>0.05）. Conclusion：Compound articaine has a reliable effect in EN-DCR combined with stent implantation and is a modified local anesthetic which can replace 2% lidocaine for infiltration anesthesia.