Association between serum level of high-density lipoprotein-associated sphingosine 1-phosphate and coronary artery stenosis

Abstract:

Objective：To explore the association between serum level of high-density lipoprotein-associated sphingosine 1-phosphate （HDL-S1P） and coronary artery stenosis. Methods：A total of 40 patients confirmed by coronary angiography with coronary artery stenosis were selected as stenosis group，while 40 others confirmed without stenosis were selected as control group. General clinical data of the two groups were collected. HDL was isolated from serum by ultracentrifugation，and HDL-S1P concentration was de－termined by high-performance liquid chromatography. C-reactive protein concentration was determined by enzyme-linked immunosor－bent assay. Multivariate analysis was performed to assess the association of HDL-S1P and C-reactive protein with coronary artery stenosis. Results：Compared with the control group，the stenosis group had significantly lower serum levels of total S1P，HDL-S1P，and HDL and a significantly higher C-reactive protein concentration[HDL-S1P：（34.17±10.62） ng/mL vs. （44.66±11.94） ng/mL，P=0.000；HDL：（1.01±0.24） mmol/L vs. （1.18±0.39） mmol/L，P=0.024；C-reactive protein：（2.96±1.40） mg/L vs. （2.10±0.99） mg/L，P=0.002]. Stepwise logistic regression analysis showed that HDL-S1P was an independent protective factor for coronary artery stenosis（OR=0.904，95%CI=0.856 to 0.956，P=0.000），while C-reactive protein was an independent risk factor（OR=1.734，95%CI=1.121 to 2.682，P=0.013）. Conclusion：HDL-S1P might be an independent predictor of coronary artery stenosis，the development of which may be associated with a decrease in serum HDL-S1P.