A clinical analysis of asymptomatic hypercholanaemia of pregnancy

Abstract:

Objective：To investigate the clinical characteristics of asymptomatic hypercholanaemia of pregnancy（AHP），and to compare them with those of intrahepatic cholestasis of pregnancy（ICP）. Methods：The clinical data were collected from 94 women with AHP，257 women with ICP，and 284 normal pregnant women admitted to the First Affiliated Hospital of Chongqing Medical University from July 2015 to April 2018；then the clinical data were analyzed retrospectively. Results：The proportion of women with early-onset（<28 weeks） AHP was significantly higher than that of women with early-onset ICP （44.7% vs. 13.2%，P<0.05）. The incidence rate of ad－verse pregnancy outcome in the AHP group was significantly higher than that in the control group，but was significantly lower than that in the ICP group（28.7%，10.9%，and 50.2%，respectively，P<0.017）. The ICP group with high serum total bile acid（TBA）（≥40 μmol/L） had significantly higher incidence rates of iatrogenic preterm labor，spontaneous preterm birth，amniotic fluid turbidity，fetal distress，and transfer to neonatal intensive care unit（NICU） compared with the ICP group with low TBA（<40 μmol/L）（P<0.05）. There were no significant differences in the incidence rates of adverse pregnancy outcomes between the AHP groups with high and low TBA（P>0.05）. The incidence rates of iatrogenic preterm labor and transfer to NICU were significantly lower in the AHP group with high TBA than in the ICP group with high TBA（P<0.05）；the incidence rate of amniotic fluid turbidity was significantly lower in the AHP group with low TBA than in the ICP group with low TBA（P<0.05）. Conclusion：The clinical characteristics of wom－en with AHP are different from those of women with ICP，which may increase the risk of adverse pregnancy outcome.