Research advances in the regulatory effect of miR-214 on bone metabolism

Abstract:

Various cells in the bone are strictly regulated to maintain bone homoeostasis. Abnormal regulation leads to many bone diseases such as osteoporosis，osteoarthritis，and delayed fracture healing. MicroRNA，a type of non-coding RNAs，is a key regulator of bone metabolism and involved in the regulation of proliferation，differentiation，and function of bone marrow mesenchymal stem cells，osteoblasts，bone cells，osteoclasts，and chondrocytes，thereby affecting the homoeostasis of bone metabolism. Previous studies have demonstrated that miR-214 affects bone metabolism by targeting genes such as β-catenin，activating transcription factor 4，fibroblast growth factor receptor 1，c-Jun N-terminal kinase，p38，Osterix，and phosphatase and tensin homolog. Moreover，miR-214 has an impact on the development，progression，and prognosis of some bone metabolism diseases such as osteosarcoma and osteoporosis via cell adhesion molecule 1，Rho-associated coiled-coil kinase 1，and other related bone metabolism regulators. Recent studies have shown that two autophagy-related genes，autophagy-related gene 12 and GABAA-receptor-associated protein，are also target genes of miR-214，suggesting that miR-214 may affect bone metabolism by regulating autophagy of bone cells. This article aims to elucidate the regulatory mechanism of miR-214 by reviewing domestic and international literature on miR-214 and bone metabolism