Abstract:With the aggravation of population aging, Alzheimer"s disease (AD), as an irreversible neurodegenerative disease, plagues people all over the world and brings heavy burden to families and society.Acupuncture play an increasingly important role in the clinical treatment of AD with its advantages of safety, simplicity and good effect.This paper summarizes the molecular biology research of acupuncture in the treatment of AD in the past five years.It summarizes the effects of acupuncture on AD through regulating the level of abnormal proteins, regulating the central cholinergic system, protecting neurons, regulating energy metabolism, inhibiting inflammatory response, and increasing the level of autophagic activity. It provides a theoretical basis for the clinical application of acupuncture in the treatment of AD.