Research advances in Helicobacter pylori infection and gastrointestinal microecology

Abstract:

The homeostasis of gastrointestinal microecology plays a critical role in maintaining normal host physiological activity. He－licobacter pylori（Hp） is a common pathogenic bacterium in the stomach and can cause gastric mucosal injury and even gastric cancer after infection. Hp colonization in the stomach can affect the homeostasis of gastrointestinal microecology，and gastrointestinal micro－biota may be involved in the pathogenic process of Hp and thus affect the outcome of Hp infection. This article reviews the interaction between Hp infection and gastrointestinal microbiota and its influence on the pathogenesis of Hp，and reveals the influence of Hp in－fection on gastrointestinal microecology，the role of gastrointestinal microecology in the pathogenesis of Hp infection，and the signifi－cance of probiotics in Hp eradication.