Research advances in the relationship between Notch signaling and proliferation and differentiation of oligodendrocyte precursor cells

Abstract:

Central nervous system（CNS） demyelination is a neuropathic disease characterized by demyelination with relatively little involvement of neuronal bodies and axons，and oligodendrocyte damage is the leading cause of CNS demyelination. Enhancing the proliferation and differentiation of oligodendrocyte precursor cells（OPCs） can improve myelin repair. Therefore，studying the mecha－nism of proliferation and differentiation of OPCs can provide a new idea and new target for the treatment of demyelinating diseases. Notch signaling is an evolutionarily highly conserved signal transduction pathway widely found in eukaryotes and prokaryotes and is closely related to the differentiation and development of cells，tissues，and organs. In recent years，studies have found that Notch sig－naling plays an important role in the regeneration of myelin. This article briefly reviews the role of Notch signaling in the proliferation and differentiation of OPCs.