Role and mechanism of HuR in development and treatment of glioma

Abstract:

Glioma is one of the most common primary nervous system tumors，with high heterogeneity，high resistance to regular treatment，high relapse and high malignancy grade. HuR is a RNA-binding protein that belongs to the ELAV gene family，and is always up-regulating in glioma tissues. It regulates cell proliferation，differentiation and survival through post-transcriptional regulation to promote tumor progression，suggesting that HuR can be an important target for treatment and prognosis of glioma. In this review，we summarized HuR’s structural features，expression in gliomas，mechanisms to mediate glioma’s development and progression，as well as related therapies.