An analysis of serum uric acid and its effect in patients with recurrent depressive disorder

Abstract:

Objective：To investigate serum uric acid in peripheral blood and its association with clinical features in patients with re－current depressive disorder. Methods：Serum uric acid was measured in 128 patients with recurrent depressive disorder（recurrent depressive disorder group），120 patients with first-episode depressive disorder（first-episode depressive disorder group），and 252 healthy controls（control group）. Patient health questionnaire-9（PHQ-9） and generalized anxiety disorder-7（GAD-7） were applied to assess the severity of depression and anxiety in the two diseased groups. Results：①Multiple linear regression analysis was performed and the results showed that the recurrent depressive disorder group and first-episode depressive disorder group had significantly lower serum uric acid levels than the control group（β=-0.327，P<0.001；β=-0.154，P<0.001），and the recurrent depressive disorder group had a significantly lower serum uric acid level than the first-episode depressive disorder group（β=-0.169，P<0.001）. ②The serum uric acid level in the recurrent depressive disorder group was negatively correlated with the duration of episode（r=-0.242，P<0.001）. Conclusion：Reduced antioxidative capacity might be associated with depressive disorder. Patients with recurrent depressive disorder have significantly reduced levels of antioxidant，which is also associated with the duration of episode.