Evaluation of the efficacy of conbercept in single treatment of nAMD by SD-OCT in combination with mf-ERG

Abstract:

Objective：To observe the effect of a single intravitreal injection of conbercept in the treatment of neovascular age-related macular degeneration（nAMD），to evaluate the short-term efficacy of conbercept in the treatment of nAMD through investigating the correlation between retinal anatomy and retinal function by spectral-domain optical coherence tomography（SD-OCT） and multifocal electroretinogram（mf-ERG），and to explore the value of mf-ERG in predicting therapeutic effect and optimizing therapeutic regimen. Methods：A retrospective analysis was conducted in 36 patients with nAMD（36 eyes）. All patients were treated with a single intravit－real injection of conbercept 0.05 mL/0.5 mg. The best corrected visual acuity（BCVA），the central retinal macular thickness（CRT），the volume of RPE uplift in the 1，3，and 6 mm circles with the macula lutea as the center（1RV，3RV，6RV），and the amplitude density and latency of P1 wave in mf-ERG R1 ring were recorded before and at 1 month after treatment. Statistical analysis was performed using SPSS 22.0 software. Continuous data were compared between two groups using the paired t-test，and the correlation between macular structure and function was evaluated by Pearson cor－relation analysis，with a test level of 0.05. Results：After treat－ment with conbercept in the 36 eyes of 36 patients，the mean BCVA significantly improved（0.19±0.16 vs. 0.26±0.17），the mean CRT significantly decreased[（472.14±181.53） μm vs. （389.5±124.79） μm]，the mean 1RV significantly decreased[（0.36±0.14） mm3 vs. （0.31±0.11） mm3]，the mean 3RV significantly decreased[（3.04±0.98） mm3 vs. （2.59±0.71） mm3]，and the mean 6RV significantly decreased[（8.17±2.91） mm3 vs. （6.66±2.38） mm3] （all P<0.01）. The amplitude density of P1 wave signifi－cantly increased from （36.47±14.25） nv/deg2 before treatment to （47.21±13.13） nv/deg2 after treatment（P<0.01），while the latency of P1 wave showed no significant change after treatment[（38.13±9.75） ms vs. （39.21±9.62） ms，P>0.05]. BCVA had a significant negative correlation with CRT，1RV，3RV，and 6RV before and after operation，but a significant positive correlation with the amplitude density and latency of P1 wave；CRT，3RV and 6RV were significantly negatively correlated with the amplitude density of P1 wave before and after operation（P<0.05）. Subconjunctival hemorrhage occurred in 3 eyes of 3 patients after injection，and all recovered after treatment. No serious ocular and systemic complications were noticed in any of the patients during follow-up. Conclusion：Conbercept has definite short-term efficacy in the treatment of nAMD，which can improve the visual acuity of the affected eyes，and restore the structure and function of the retina with a high safety. BCVA and SD-OCT combined with mf-ERG are more objective and compre－hensive in evaluating the treatment outcome of nAMD，and mf-ERG is expected to be an objective functional indicator for evalu－ating the efficacy and judging the re-treatment during the treatment of nAMD.