Researchadvancesintheroleofmesenchymalstemcellexosomesintreatmentofdiabeticnephropathy
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    Abstract:

    Diabeticnephropathy(DN)hasbecomeamajorproblemaffectinghumanhealth,andthepreventionandtreatmentofitsdevelopmentandprogressionhasattractedmoreandmoreattentionintheindustry.Inrecentyears,stemcelltransplantationhasshowngreatpotentialinthepreventionandtreatmentofDN,especiallymesenchymalstemcells(MSCs)transplantation.MoreandmorestudieshaveshownthatMSCsmainlyexertatherapeuticeffectinaparacrinemode,andaseriesofnanoscalevesicles(exosomes)releasedbyMSCsactasanimportantmediatorforintercellularcommunication.Theseexosomescantransferstemcellphenotypetorecipientcells,promotestemcellmaintenance,differentiation,self-renewal,andrepair,mediateinteractionsbetweenmatrixelements,andpro-motetissuerepairandregenerationofrecipientcells.Stemcellexosome-mediatedtreatmentofchronickidneydiseasehasbecomearesearchhotspotinrecentyears,andsomeachievementshavebeenmadeinthetreatmentofDN.Thisarticlereviewstherecentad-vancesinstemcellexosomesinthetreatmentofDNinChinaandforeigncountries.

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LiShaobin, TangMi, YangYibin. Researchadvancesintheroleofmesenchymalstemcellexosomesintreatmentofdiabeticnephropathy[J]. Journal of Chongqing Medical University,2020,45(3):294-

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  • Received:
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  • Online: April 28,2020
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