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Applicationprospectofendothelialprogenitorcellsonpreventionandtreatmentofdiabetes-relatedcardiovasculardiseases
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    Abstract:

    TheincidenceandmortalityofdiabetesinChinaareincreasingyearbyyear，andvascularcomplicationssecondarytodiabeteshaveprovedtobethemaincauseofdeathindiabeticpatients.Endothelialprogenitorcells（EPCs）canpromoteangiogenesisandrepairimpairedvessels，whileEPCsdepletionanddysfunctionleadtothedevelopmentofdiabeticangiopathy.ThisarticlereviewstheroleofEPCsintreatmentandpreventionofdiabetes-relatedcardiovasculardiseases.EPCsprovideanewapproachtothetreat－mentofdiabetes-inducedcardiovasculardiseases.Althoughpositiveeffectsweredocumentedbyanimalstudybothinvivoandvitro，clinicaltrialswithlargesamplearestillrequiredtoverifytheefficiencyandsafetyofEPCstransplantationtherapyinpatientswithdiabetes-inducedcardiovasculardiseases.Moderatealcoholconsumption，useofestrogenandstains，aswellasphysicalexerciseetc.canstimulateEPCstomobilize，proliferateandmigrate，theycanalsopromoteangiogenesis，whichisofgreatsignificanceforthetreatmentofdiabetesinducedcardiovasculardiseases.

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ZhaiLu, LiuYuhua, HuangYanfeng, MaCui, HuangShan, ZhangQiu, ZhongXin, DaiXia. Applicationprospectofendothelialprogenitorcellsonpreventionandtreatmentofdiabetes-relatedcardiovasculardiseases[J]. Journal of Chongqing Medical University,2020,45(3):301-

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  • Online: April 28,2020
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