Formation of adipocytes in the involution phase of infantile hemangioma

Abstract:

Infantile hemangioma is a common benign vascular tumor of infancy. Involution often commences within several years after onset in most infants，but some patients still cannot achieve spontaneous regression. Infantile hemangioma may also cause a series of sequelae. Therefore，the research on the mechanism of involution is the key to normal involution of infantile hemangioma. The forma－tion of adipocytes is an important pathological feature of infantile hemangioma in the involution phase，and adipogenic progenitor cells have always been a controversial topic in the academic community. With reference to the latest research advances，this article discusses the source of the large number of adipocytes that appear in the involution phase of infantile hemangioma and elaborates on the histo－logical and cytological viewpoints and the role of endothelial-mesenchymal transition，in order to provide new thoughts for clinical in－tervention of infantile hemangioma.