Risk factors for contrast-induced acute kidney injury in Han and Uyghur populations of Tianjin and Hetian，China：a comparative study

Abstract:

Objective：To determine whether the incidence rate and risk and influencing factors for contrast-induced acute kidney in－jury（CI-AKI） in Uyghur patients in Hetian of Xinjiang，China are different from those in Han patients，and to gain insights into mea－sures that reduce the incidence and improve the prognosis of Uyghur CI-AKI patients. Methods：The clinical data of 486 patients who underwent percutaneous coronary intervention（PCI） and had postoperative renal function examination in Tianjin Chest Hospital and Hetian District People’s Hospital of Xinjiang Uygur Autonomous Region were reviewed. Patients were divided according to their eth－nicity and the presence or absence of CI-AKI，and differences in risk factors and influencing factors were examined. Significant pa－rameters identified by the one-way ANOVA were subjected to logistic analysis. Results：Uyghur patients in Hetian had a significantly higher incidence rate of CI-AKI than Han patients in Tianjin （21.10% vs. 8.96%，P<0.001）. The rate of use of diuretic was significantly lower in total Han patients and Han CI-AKI patients than in total Uyghur patients and Uyghur CI-AKI patients（total patients：1.5% vs. 10.1%，P<0.001；CI-AKI patients：4.2% vs. 23.9%，P=0.047）. In addition，N-terminal pro-brain natriuretic peptide（NT-proBNP） level was significantly lower in total Han patients than in total Uyghur patients[（860.58±93.89） ng/L vs. （1905.67±101.47） ng/L，P=0.024]，and significantly lower in Han CI-AKI patients than in Uyghur CI-AKI patients[（1509.70±327.69） ng/L vs. （2984.20±346.94） ng/L，P=0.019]. Similarly，high-sensitivity C-reactive protein level was also significantly lower in total Han patients than in total Uyghur patients[（4.33±0.97） mg/L vs. （18.34±2.07） mg/L，P<0.001]，and significantly lower in Han CI-AKI patients than in Uyghur CI-AKI patients[（8.64±1.30） mg/L vs. （20.27±4.51） mg/L，P<0.001]. Compared with Uyghur pa－tients without CI-AKI，those with CI-AKI had significantly different rate of use of RAAS inhibitors（43.5% vs. 66.3%，P=0.005），dose of contrast agents[（162.41±18.63） mL vs. （126.93±12.63） mL，P=0.002]，left ventricular ejection fraction[（48.54±6.23）% vs. （54.34±5.52）%，P<0.001]，and NT-proBNP level[（2 984.20±346.94） mL vs. （1 636.04±134.27） mL，P=0.018]. Conclusion：Increasing the use of preoperative RAAS，im－proving cardiac function，and reducing postoperative diuretic can lower the risk of post-PCI CI-AKI in Uyghur patients.