Interleukin-6-572 gene polymorphism in hypertensive patients with renal damage and its association with benazepril treatment response

Abstract:

Objective：To study the association of interleukine-6（IL-6）-572 C/G polymorphism with hypertensive renal damage and the therapeutic effect of benazepril. Methods：Two hundred and eighty-four patients who were initially diagnosed with hypertension were enrolled，and then 24-h urinary albumin excretion rate（UAER） was measured. According to the results，the patients were divid－ed into hypertension group（UAER <20 ?滋g/min） and hypertensive renal damage group（UAER≥20 ?滋g/min）. The plasma levels of IL-6 were measured by enzyme-linked immunosorbent assay，and the IL-6-572 C/G gene polymorphism was determined by polymerase chain reaction-restriction fragment length polymorphism. One hundred and sixty healthy subjects were selected as normotensive group. Then the patients were treated with benazepril as a basic antihypertensive drug，and the relationship between IL-6-572 C/G polymor－phism and the therapeutic effect of benazepril was evaluated. Results：In the normotensive group，the most common genotype of IL-6-572 C/G was GG，followed by GC and CC，with a C/G frequency of 40% and 60%，respectively；in the hypertensive group，CC was the most common genotype of IL-6-572 C/G，followed by GG and GC，with a C/G frequency of 51% and 49%，respectively；in the hyper－tensive renal damage group，CG was the most common genotype，followed by CC and GG，with a C/G frequency of 58% and 42%，respectively. There were significant differences in polymorphism and G/C frequency between the three groups（P<0.05）. The pa－tients with IL-6-572 GG genotype showed the greatest changes in IL-6 and UAER after benazepril therapy，followed by those with CC and CG genotypes. Conclusion：IL-6-572 C/G poly－morphism is associated with hypertensive renal damage and the response to benazepril therapy. Detection of IL-6-572 C/G genotype is useful for identifying high-risk patients with hypertensive renal damage and predicting the therapeutic effect of benazepril，so as to aid in the prevention and treatment of hypertensive renal damage.