Relationship between serum 25-hydroxyvitamin D level and dyslipidemia in elderly patients with primary hypertension

Abstract:

Objective：To investigate the nutritional status of serum 25-hydroxyvitamin D[25（OH）D] in elderly patients with primary hypertension，and to explore the relationship between 25（OH）D level and dyslipidemia. Methods：A total of 185 elderly patients with primary hypertension were enrolled. The concentration of 25（OH）D was measured，and general information，blood glucose，blood lipids，and other data were collected. Patients were divided into four groups（Q1-Q4） according to the quartiles of their serum 25（OH）D levels. The correlation between serum 25（OH）D level and blood lipid profiles was analyzed，and binary logistic regression analysis was used to analyze the relevant influencing factors for dyslipidemia. Eighty patients with vitamin D deficiency and dyslipidemia were se－lected（after signing informed consent），and were randomly divided into supplemented group and unsupplemented group. Both groups took atorvastatin calcium oral tablets（20 mg per night） to lower lipids，and the supplemented group took additional vitamin D3（400 U per day） based on lifestyle guidance. Serum 25（OH）D levels and blood lipids were measured again 3 months later. Results：The pro－portion of 25（OH）D deficiency cases in elderly patients with primary hypertension was as high as 70.3%. Compared with the Q4（highest） group，the Q1（lowest） group had significantly increased triglyceride（TG），total cholesterol（TC），and low density lipoprotein cholesterol（LDL-C） levels，a significantly reduced high density lipoprotein cholesterol（HDL-C） level，and a significantly increased incidence of dyslipidemia. Correlation analysis showed that serum 25（OH）D was negatively correlated with TG，TC，LDL-C，and dys－lipidemia and was positively correlated with HDL-C. After adjusting for the other influencing factors，logistic regression analysis found that serum 25（OH）D was independently associated with the development of dyslipidemia. Serum 25（OH）D increased significantly in the supplemented group after 3 months，and the improvement in blood lipid profiles in the supplemented group was significantly better than that in the unsupplemented group. Conclusion：Serum 25（OH）D deficiency is common in elderly patients with primary hypertension，and 25（OH）D level is associated with dyslipi－demia. In the diagnosis and treatment of dyslipidemia in elder－ly patients with primary hypertension，vitamin D supplementa－tion can help improve dyslipidemia.